RESEARCH MONOGRAPH · KDC-MN-099
Fisetin
Fisetin is a natural flavonoid found in strawberries and apples that selectively kills senescent cells (a senolytic). Mayo Clinic researchers identified it in screens looking for natural compounds with senolytic activity. Clinical trials are ongoing. Not stocked by Kodiac. This monograph is provided for research and educational reference.
Intrigue 0–100 blends mechanism novelty, evidence strength, and translational potential. Kodiac editorial, not peer-reviewed.
Flavonoid senolytic
A flavonoid present in strawberries and other fruits, characterized as a senolytic that selectively eliminates senescent cells in animal models.
Abstract
Fisetin (3,3',4',7-tetrahydroxyflavone; CAS 528-48-3; molecular formula C15H10O6; molecular weight 286.24) is a flavonoid present in strawberries, apples, persimmons, and many other plants. The compound was identified by James Kirkland's group at Mayo Clinic as one of the most potent natural senolytic compounds in screening assays; senolytics selectively kill senescent cells while sparing healthy cells. In aged mice, fisetin reduces senescent cell burden in adipose tissue and other organs, modestly extends lifespan, and improves age-related functional measures. Pharmacology includes inhibition of senescent cell anti-apoptotic networks (SCAP) and Bcl-2 family modulation. The clinical investigation base is early; small Phase 1 and Phase 2 trials are underway in age-related conditions. The compound is sold as a dietary supplement. Reported research dose ranges in the literature for senolytic applications are typically pulsatile (concentrated over 2 to 3 day windows) at 100 to 1000 mg; the pulsatile schedule is described as a way to avoid sustained exposure that would lose senolytic specificity.
Mechanism of action
Senolytic compound that selectively eliminates senescent cells through SCAP modulation and Bcl-2 family inhibition.
Reported research dose ranges
100 to 1000 mg in pulsatile windows (2-3 day windows) for senolytic research applications (reported research dose ranges in the literature).
References
- Yousefzadeh MJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine 2018.
Read the full monograph
The full reference document covers compound identification, discovery and developmental history, mechanism of action, pharmacokinetics, reported research dose ranges, sourcing and quality verification, reconstitution and handling, stack interaction considerations, and a curated reference list. Available as a research-use-only PDF download.
The full reference document is provided strictly for research use only. It reports research dose ranges from the published literature, not instructions for use in humans or animals.
FOR RESEARCH USE ONLY. Not for medical, diagnostic, or therapeutic purposes. Not for human consumption. All information is provided for research and educational purposes only.