RESEARCH MONOGRAPH · KDC-MN-138
Kisspeptin
Kisspeptin is a hypothalamic neuropeptide that triggers GnRH release. It is the master regulator of puberty and reproductive hormones. Investigated for anovulatory infertility, hypogonadism, and reproductive disorders. Not stocked by Kodiac. This monograph is provided for research and educational reference.
Intrigue 0–100 blends mechanism novelty, evidence strength, and translational potential. Kodiac editorial, not peer-reviewed.
Hypothalamic neuropeptide / KISS1R agonist
An endogenous neuropeptide encoded by the KISS1 gene, master regulator of GnRH neuron firing and reproductive function.
Abstract
Kisspeptin (kisspeptin-54 and shorter active fragments including kisspeptin-10; encoded by the KISS1 gene) is an endogenous peptide identified in 2003 as the master regulator of GnRH neuron firing in the hypothalamus, controlling reproductive function and pubertal onset. Loss-of-function mutations in KISS1 or its receptor KISS1R produce hypogonadotropic hypogonadism. Exogenous kisspeptin administration stimulates LH and FSH release through GnRH neuron activation. The compound has been studied as a fertility therapeutic (induction of ovulation in functional hypothalamic amenorrhea) and as a research probe for reproductive neuroendocrine function. Pharmacokinetics: plasma half-life of kisspeptin-54 is ~30 minutes; kisspeptin-10 has shorter half-life. Research doses are highly variable; reported research dose ranges in the literature are described in the source publications.
Mechanism of action
KISS1R receptor agonist; activates GnRH neurons. Master regulator of reproductive endocrine axis.
Reported research dose ranges
Reported research dose ranges in the literature.
References
- Seminara SB, et al. The GPR54 gene as a regulator of puberty. N Engl J Med 2003.
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The full reference document is provided strictly for research use only. It reports research dose ranges from the published literature, not instructions for use in humans or animals.
FOR RESEARCH USE ONLY. Not for medical, diagnostic, or therapeutic purposes. Not for human consumption. All information is provided for research and educational purposes only.