Nootropic of the week
COGNITIVE / Week 1 of 3
A small angiotensin IV analog with a contested mechanism of action, a high-profile commercialization failure, and a literature record selectively retracted in 2025.
Monographs
Per-compound research monographs covering chemistry, mechanism, pharmacokinetics, sourcing, and references. Each is a formal reference document with embedded PDF, formatted to standards comparable to peer-reviewed reviews.
764 compounds on file 4 flagged novel
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KDC-MN-014 Novel 68/100 5-Amino-1MQ
Small-molecule selective NNMT inhibitor (capsule format)
A 159 Da quinolinium small molecule that selectively inhibits nicotinamide N-methyltransferase, characterized for effects on adipose metabolism and skeletal muscle stem cell fun...
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KDC-MN-015 Novel 62/100 9-Me-BC
Beta-carboline alkaloid dopaminergic neuroprotective small molecule (capsule format)
A 182 Da methylated beta-carboline alkaloid characterized for dopaminergic neuroprotective effects, increased dopamine neuron differentiation, and BDNF expression in animal mode...
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KDC-MN-001 Novel 68/100 Dihexa
Angiotensin IV analog (procognitive small peptidomimetic)
A small angiotensin IV analog with a contested mechanism of action, a high-profile commercialization failure, and a literature record selectively retracted in 2025.
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KDC-MN-012 Novel 73/100 SS-31
Synthetic tetrapeptide mitochondrial-targeting cardiolipin-binding peptide
A 4-amino-acid mitochondrial-targeting peptide developed at Cornell University, characterized for binding to cardiolipin in the inner mitochondrial membrane and protecting mitoc...
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KDC-MN-011 72/100 Semax
Synthetic heptapeptide nootropic ACTH(4-10) analog
A 7-residue peptide derived from ACTH(4-10), developed at the Russian Academy of Sciences and registered for clinical use in stroke recovery and cognitive indications.
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KDC-MN-010 72/100 Selank
Synthetic heptapeptide anxiolytic tuftsin analog
A 7-residue peptide developed at the Russian Academy of Sciences as a stable analog of tuftsin, characterized for anxiolytic, immunomodulatory, and cognitive endpoints in a subs...
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KDC-MN-008 72/100 MOTS-c
16-residue mitochondrial-derived peptide AMPK pathway modulator
A short open reading frame encoded within mitochondrial 12S rRNA, reported to modulate insulin sensitivity, exercise capacity, and metabolic homeostasis through AMPK-dependent m...
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KDC-MN-009 74/100 KPV
Tripeptide C-terminal fragment of alpha-melanocyte stimulating hormone
A 3-amino-acid tripeptide derived from the C-terminus of alpha-MSH, characterized for anti-inflammatory effects in colitis, dermatitis, and hepatic injury models.
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KDC-MN-007 77/100 GHK-Cu
Tripeptide-copper(II) complex copper transport peptide
A naturally occurring tripeptide that binds copper(II) with very high affinity, characterized as a wound healing and tissue remodeling peptide with a substantial multidisciplina...
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KDC-MN-006 58/100 Epitalon
Synthetic tetrapeptide telomerase modulator and bioregulator
A 4-residue synthetic peptide developed in St. Petersburg, studied principally for telomerase modulation, pineal function, and circadian rhythm endpoints in a literature dominat...
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KDC-MN-005 75/100 CJC-1295 (No DAC)
Synthetic 29-residue analog of growth hormone-releasing hormone
A 29-amino-acid GHRH analog with four point substitutions that confer enzymatic stability against dipeptidyl peptidase 4, the principal degradation pathway for native GHRH.
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KDC-MN-004 80/100 Ipamorelin
Pentapeptide growth hormone secretagogue ghrelin receptor agonist
A 5-residue selective growth hormone secretagogue developed at Novo Nordisk in the late 1990s, characterized by GH release without coincident ACTH or prolactin stimulation.
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KDC-MN-003 63/100 TB-500
Synthetic peptide fragment of thymosin beta-4
A 43-residue acetylated synthetic peptide derived from the actin-sequestering protein thymosin beta-4, studied for tissue repair, cell migration, and angiogenic endpoints.
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KDC-MN-002 72/100 BPC-157
Pentadecapeptide (gastric BPC fragment)
A 15-amino-acid sequence derived from a gastric protective protein, broadly studied in tendon, ligament, vascular, and gut repair models.
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